I replaced a 400 with a 460 in a 73LTD back in high school and sold it to my brother. 
My advice, find a parts car. In typical ford fashion, practically anything that can be different, is.
I remember replacing motor mounts, throttle cable, having a custom exhaust made... and a buncha' other stuff I can't remember right now.
A parts car will make all the difference. A lot of those big cars had 460's, so it shouldn't be too hard. Back then, the junkyards were littered with them. I purchased his running 460 complete (w/D0VE heads) for the grand sum of $125, and didn't have to even pull a valve cover. 
Good Luck!
------------------
Mike Burch
66 mustang real street
302 4-speed 289 heads
10.63 @ 129.3
http://www.geocities.com/motorcitymustang/cmml/cmml_mburch.html
http://www.fortunecity.com/silverstone/healey/367